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Gastrointestinal endoscopy is one of the most common invasive procedures carried out in pediatric gastroenterology and is not without risk. The range of necessary measures for the purpose of this procedure includes: the accurate assessment of the patient considering the endoscopy-related indications and contraindications, obtaining the informed consent, the psychological preparation of the parents/child, applying some dietary restrictions, and infection prophylaxis. It is also necessary to choose the type of sedation and ensure the constant monitoring during and after the procedure so as to avoid any complications related to the procedure or to the side effects of drugs.