A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
oleh: D. J. Kemp, J. Thompson, D. A. Barnes, T. Triglia, F. Karamalis, C. Petersen, G. V. Brown, K. P. Day
| Format: | Article |
|---|---|
| Diterbitkan: | Fundação Oswaldo Cruz (FIOCRUZ) 1992-01-01 |
Deskripsi
Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.