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Five putrescine and spermidine derivatives (<b>1</b>–<b>5</b>) together with five rotenoids (<b>6</b>–<b>10</b>) were isolated from a methanolic extract of the flowers of <i>A. fruticosa</i> that displayed promising inhibition of 76.0 ± 1.9% for AChE and 90.0 ± 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-<i>trans</i>-tri-<i>p</i>-coumaroylspermidine and <i>trans</i>-<i>trans</i>-<i>cis</i>-tri-<i>p</i>-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.