Soluble Klotho protects against glomerular injury through regulation of ER stress response
oleh: Emmanuelle Charrin, Dina Dabaghie, Ilke Sen, David Unnersjö-Jess, Katja Möller-Hackbarth, Mikhail Burmakin, Rik Mencke, Sonia Zambrano, Jaakko Patrakka, Hannes Olauson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
Transgenic overexpression of αKlotho in hepatocytes results in protection against renal insults, possibly through modulation of the ER stress response by circulating αKlotho. In contrast, αKlotho overexpressed in podocytes is not renoprotective.