Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines
oleh: Jianzhong Chen, Zhenfeng Zhang, Bowen Li, Feilong Li, Yulin Wang, Min Zhao, Ilya D. Gridnev, Tsuneo Imamoto, Wanbin Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Sterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites.