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Abstract Background and aims: Sleep quality is defined as the perceived deep sleep. More than half of nurses have sleep disorders. The aim of this study is to compare perceived sleep quality between burn and non-burn nurses. Methods: In a cross-sectional design in Imam Reza Hospital in 2016, 55 nurses of burn ward were compared to a representative sample of other clinical wards. The validated Persian version of Pittsburgh Sleep Quality Index was filled. Data were analyzed through SPSS v. 11.5. Results: All burn nurses (55, 100%) and 96% (48) of non-burn nurses had a sleep disorder without a statistically significant difference. Only sleep efficiency was better in burn nurses (85% with no sleep disorder) compared to non-burn nurses (64% with no sleep disorder) (p=0.01). Sleep quality was significantly reduced by increasing age (r= -0.23, p=0.02) and increasing years of work history (r= -0.23, p=0.01) but not with overtime work (r=0.08, p=0.38). Conclusion: With respect to the high prevalence of sleep disorder, we believe that screening interventions should be considered in the nursing system. This approach can hopefully help in starting therapeutic interventions to reduce or even eliminate the burden of sleep disorder.   Keywords: Sleep Quality, Nurse, Clinical Ward, Pittsburgh Questionnaire