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Intestinal microbiota such as <i>Fusobacterium nucleatum</i> play an important role in the pathogenesis of colorectal cancer. Here, we describe the case of a 47-year-old patient presenting with endophthalmitis and a liver abscess due to <i>Fusobacterium nucleatum</i> that prompted the diagnosis of colorectal cancer as the most likely source of infection. This case highlights that colorectal cancer needs to be considered in patients with systemic infection with <i>Fusobacterium nucleatum</i> and colonoscopy should be performed.