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Coldmix^® is a commercially available <i>Eucalyptus aetheroleum</i> and, <i>Abies aetheroleum</i> blend for medicinal applications. In this present study, the in vitro antiviral potential of Coldmix^®, and its major constituents 1,8-cineole and α-pinene were evaluated by using the in vitro ACE2 enzyme inhibition assay as well as the direct contact test against SARS-CoV-2. The observed ACE2 enzyme inhibitory activity of Coldmix^®, 1,8-cineole, and α-pinene were 72%, 88%, and 80%, respectively; whereas in the direct contact test in the vapor phase, the destruction of the virus was 79.9% within 5 min and 93.2% in the 30th min, respectively. In a similar Coldmix^® vapor phase setup using the in vitro cytotoxicity cell assay, E6 VERO healthy cells were experimentally not affected by toxicity. According to the promising initial antiviral results of Coldmix^® and the individually tested constituents, detailed further in vivo evaluation using different virus classes is suggested.