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Toxicology screening of unusual poisons is important. We report a case of death of a young female suspected to die due to drug overdose. Medico legal autopsy was indicative of cerebral hemorrhage. The deceased had no previous history of drug dependence. Toxicological analysis revealed the presence of cathine {(+)-norpseudoephedrine} and alcohol in the blood. The concentration of ethyl alcohol in blood was determined as 85.57 mg per dL. An overview of toxicology of cathine and its side effects are presented. The reports due to fatal intoxication of cathine in combination with alcohol are rarely reported. The present case substantiates that an intake of low potent drug like cathine in combination with alcohol can cause fatal intoxication.