A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
oleh: Yufeng Yao, Qiulun Lu, Zhenkun Hu, Yubin Yu, Qiuyun Chen, Qing K. Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-07-01 |
Deskripsi
Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectively treat cardiac hypertrophy and heart failure.