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A randomized trial was conducted in 22 patients with a body mass index of 44.9 ± 1.6 kg/m2 and morbid obesity who underwent endoscopic sleeve gastroplasty. According to the mode of anesthesia, the patients were divided into two groups: 1) concomitant anesthesia based on low-flow sevoflurane inhalation in combination with continuous epidural 0.2% ropivacaine analgesia (n = 12); 2) concomitant anesthesia based on low-flow desflurane inhalation in combination with continuous epidural 0.2% ropivacaine analgesia (n = 10). The indicators of central and peripheral hemodynamics and external respiratory function were examined; neuromuscular conduction was monitored; and the efficiency of postoperative rehabilitation was evaluated. Surgery under low-flow inhalational anesthesia with desflurane was established to contribute to prompter postanesthetic rehabilitation.