Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
oleh: Jean Paul ten Klooster, Marianne Bol-Schoenmakers, Kitty van Summeren, Arno L. W. van Vliet, Cornelis A. M. de Haan, Frank J. M. van Kuppeveld, Saertje Verkoeijen, Raymond Pieters
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
ten Klooster et al. use ileum-derived organoids and report that bacterial and viral stimuli can drive IL22 production by T cells via distinct signaling pathways, and that IL22 can stimulate expression of anti-microbial and antiviral factors. This study sheds light on how enterocytes, fibroblasts and myeloid cells work synergistically to induce IL22 response against both bacteria and viruses.