Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
oleh: Valerie Cortez, David F. Boyd, Jeremy Chase Crawford, Bridgett Sharp, Brandi Livingston, Hannah M. Rowe, Amy Davis, Ramzi Alsallaq, Camenzind G. Robinson, Peter Vogel, Jason W. Rosch, Elisa Margolis, Paul G. Thomas, Stacey Schultz-Cherry
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut.