Helical structure motifs made searchable for functional peptide design
oleh: Cheng-Yu Tsai, Emmanuel Oluwatobi Salawu, Hongchun Li, Guan-Yu Lin, Ting-Yu Kuo, Liyin Voon, Adarsh Sharma, Kai-Di Hu, Yi-Yun Cheng, Sobha Sahoo, Lutimba Stuart, Chih-Wei Chen, Yuan-Yu Chang, Yu-Lin Lu, Simai Ke, Christopher Llynard D. Ortiz, Bai-Shan Fang, Chen-Chi Wu, Chung-Yu Lan, Hua-Wen Fu, Lee-Wei Yang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Here, we present TP-DB; a pattern-based search engine based on 1.67 million helices from the Protein Database (PDB). We demonstrate the utility of TP-DB in identifying microbe-specific antigens, as well as the design of antimicrobial peptides and Protein-protein interaction blockers.