The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
oleh: Jordi Ribera, Irene Portolés, Bernat Córdoba-Jover, Juan Rodríguez-Vita, Gregori Casals, Bernardino González-de la Presa, Mariona Graupera, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, José C. Fernández-Checa, Guadalupe Soria, Raúl Tudela, Anna Esteve-Codina, Guadalupe Espadas, Eduard Sabidó, Wladimiro Jiménez, William C. Sessa, Manuel Morales-Ruiz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
Jordi Ribera et al. use zebrafish and mouse models to examine the role of the ATP-dependent RNA helicase, DHX15, in vascular health. Their results suggest that DHX15 depletion can cause vascular defects in vertebrates, potentially by impacting endothelial ATP production.