An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping
oleh: Zhao Wang, Qian Liang, Xinyi Qian, Bolang Hu, Zhanye Zheng, Jianhua Wang, Yuelin Hu, Zhengkai Bao, Ke Zhao, Yao Zhou, Xiangling Feng, Xianfu Yi, Jin Li, Jiandang Shi, Zhe Liu, Jihui Hao, Kexin Chen, Ying Yu, Pak Chung Sham, Wange Lu, Xiaoyan Wang, Weihong Song, Mulin Jun Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Here the authors used an evidence-based strategy to prioritize causal pleiotropic variants of autoimmune diseases, and revealed that rs4728142 modulates aberrant IRF5 alternative promoter usage by ZBTB3-mediated chromatin looping.