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Two bis(triorganotin) 2,6-pyridinedicarboxylates, 2,6-C5H3N(COOSnR3)2 (R=C6H11-c, 1; C6H5C(CH3)2CH2, 2), have been synthesized by the reaction of 2,6-pyridinedicarboxylic acid with triorganotin hydroxide in toluene-ethanol and characterized by means of elemental analysis, FT-IR, 1H NMR spectroscopy, and single crystal X-ray diffraction analysis. In the compounds, a 2,6-pyridinedicarboxylate dianion binds two triorganotin units in a monodentate manner and both tin atoms exist in a distorted tetrahedral environment. Bioassay results have shown that the compounds possess good in vitro cytotoxic activity against two human tumor cell lines, Hela and MCF-7.