Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived <i>Nocardiopsis aegyptia</i> HDN19-252
oleh: Luning Zhou, Xuedong Chen, Chunxiao Sun, Yimin Chang, Xiaofei Huang, Tianjiao Zhu, Guojian Zhang, Qian Che, Dehai Li
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2021-10-01 |
Deskripsi
Four new anthraquinone derivatives, namely saliniquinones G−I (<b>1</b>–<b>3</b>) and heraclemycin E (<b>4</b>), were obtained from the Antarctic marine-derived actinomycete <i>Nocardiopsis aegyptia</i> HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds <b>1</b> and <b>2</b> showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative <i>staphylococci</i> (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.