Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
oleh: Yoichi Nakao, Takeru Shiroiwa, Shigeki Matsunaga, Shuhei Murayama, Yasuyuki Goto, Yoshitsugu Matsumoto, Nobuhiro Fusetani
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2004-05-01 |
Deskripsi
Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.