Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont <i>Teredinibacter turnerae</i>
oleh: Noel M. Lacerna, Cydee Marie V. Ramones, Jose Miguel D. Robes, Myra Ruth D. Picart, Jortan O. Tun, Bailey W. Miller, Margo G. Haygood, Eric W. Schmidt, Lilibeth A. Salvador-Reyes, Gisela P. Concepcion
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2020-12-01 |
Deskripsi
The bioactivity-guided purification of the culture broth of the shipworm endosymbiont <i>Teredinibacter turnerae</i> strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (<b>1</b>), and two previously described oxylipins (<b>2</b>–<b>3</b>). Turneroic acid (<b>1</b>) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds <b>1</b>–<b>3</b> inhibited bacterial biofilm formation in <i>Staphylococcus epidermidis</i>, while only <b>3</b> showed antimicrobial activity against planktonic <i>S</i>. <i>epidermidis</i>. Comparison of the bioactivity of <b>1</b>–<b>3</b> with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.