Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
oleh: Lars Muhl, Guillem Genové, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira V. Chivukula, Åsa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Björkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-08-01 |
Deskripsi
To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.