Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
oleh: Lauren E. Carter, David P. Cook, Curtis W. McCloskey, Melanie A. Grondin, David A. Landry, Tiffany Dang, Olga Collins, Lisa F. Gamwell, Holly A. Dempster, Barbara C. Vanderhyden
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Using spheroids as a model, the authors report the molecular signatures of ovarian surface epithelial (OSE) cells exhibiting stemness phenotype under various conditions in vitro, and found that there is a large degree of heterogeneity in the transcriptional profiles of stem cells induced under different conditions. They suggest that maintenance of the OSE may not require a single stem cell population, but heterogeneous stem cells that can be induced transiently under diverse environmental cues.