New 8-Hydroxybriaranes from the Gorgonian Coral <i>Junceella fragilis</i> (Ellisellidae)
oleh: You-Ying Chen, Lee-Shing Fang, Yu-Hsin Chen, Bo-Rong Peng, Tung-Pin Su, Thanh-Hao Huynh, Feng-Yu Lin, Chiung-Chin Hu, Nai-Cheng Lin, Zhi-Hong Wen, Jih-Jung Chen, Chieh-Yu Lee, Jin-Wei Wang, Ping-Jyun Sung
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-09-01 |
Deskripsi
Three new 8-hydroxybriaranes—fragilides R−T (<b>1</b>−<b>3</b>) were obtained from a sea whip gorgonian coral <i>Junceella fragilis</i>. The structures of briaranes <b>1</b>−<b>3</b> were elucidated by using spectroscopic methods, including 1D (<sup>1</sup>H and <sup>13</sup>C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (<b>2</b> and <b>3</b>) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively. Briarane <b>2</b> exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.