A novel and practical asymmetric synthesis of eptazocine hydrobromide
oleh: Ruipeng Li, Zhenren Liu, Liang Chen, Jing Pan, Kuaile Lin, Weicheng Zhou
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2018-09-01 |
Deskripsi
In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield and purity.