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Despite numerous methods of wound care post appendectomy, no definite technique documented to be the best. Wound irrigation under pressure with syringe is regarded recently as an acceptable physical and biological way to prevent post appendectomy wound infection. This study compares the best of several method of wound infection prevention on 418 patients subjected to appendectomy and divided in different groups, including the use of systemic antibiotic, local antibiotic, povidone iodine, and saline pressure irrigation. We concluded that: syringe pressure irrigation to the wound significantly decrease post operative infection, and is best in comparison to other methods.