A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines
oleh: Alexander V. Aksenov, Nikolai A. Arutiunov, Dmitrii A. Aksenov, Artem V. Samovolov, Igor A. Kurenkov, Nicolai A. Aksenov, Elena A. Aleksandrova, Daria S. Momotova, Michael Rubin
| Format: | Article |
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| Diterbitkan: | MDPI AG 2022-09-01 |
Deskripsi
Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the corresponding quinoxalines as sole, easily isolaable products. The featured transformation involves unusual extrusion of phenylacetonitrile molecule and could be performed in a short sequence starting from commonly available indoles and nitroolefins.