Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
oleh: Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine, Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes.