Atividade antiproliferativa de Sloanea garckeana K. Schum. Antiproliferative activity of Sloanea garckeana K. Schum.

oleh: Adriano Lopes Romero, Álvaro Fontana, Cleuza Conceição da Silva, Maria Conceição de Souza, João Ernesto de Carvalho, Emiret O. Faria, Lucilia Kato, Cecília M. A. de Oliveira

Format: Article
Diterbitkan: Sociedade Brasileira de Química 2008-01-01

Deskripsi

<abstract language="eng">The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.