Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing
oleh: Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.