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Dermatitis artefacta (factitious dermatitis) is a prototypical psychodermatological condition. This condition though not uncommon its management involves complete psychiatric evaluation and treatment. It is commonly seen in patients with underlying psychological conflicts. There are no systematic studies to assess the efficacy of medicines for this condition. However, reports of improvement with selective serotonin reuptake inhibitors and atypical antipsychotics are present. Here, we report a case of dermatitis artefacta responding to high dose of sertraline.