Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses
oleh: Frederik Broszeit, Rosanne J. van Beek, Luca Unione, Theo M. Bestebroer, Digantkumar Chapla, Jeong-Yeh Yang, Kelley W. Moremen, Sander Herfst, Ron A. M. Fouchier, Robert P. de Vries, Geert-Jan Boons
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Here, Broszeit et al. show that circulating A/H3N2 viruses have evolved binding specificity to α2,6-sialosides on extended LacNAc moieties and therefore cannot agglutinate erythrocytes. Applying glycan remodeling allows to install functional receptors on erythrocytes and promotes identification of newly circulating variants to facilitate vaccine design.