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Abstract We present the analytic and compact two-loop helicity amplitudes for QCD and QED corrections to the light-by-light scattering process with massive internal fermions. We express the master integrals either in terms of multiple polylogarithms or in terms of iterated integrals with dlog one-forms. We also elaborate on optimising the analytic results for each phase-space region. This makes the numerical evaluation of the scattering amplitudes fast, stable and suitable for phenomenological applications.