Synthetic RNA-based logic computation in mammalian cells
oleh: Satoshi Matsuura, Hiroki Ono, Shunsuke Kawasaki, Yi Kuang, Yoshihiko Fujita, Hirohide Saito
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use. Here the authors construct a set of logic gates that respond to multiple miRNAs and demonstrate an apoptosis-regulatory AND gate.