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Aim: The present study was conducted to evaluate the association between serum albumin and chronic periodontitis in elderly individuals. Methodology: Sixty systemically healthy subjects in the age group of fifty and above were included in the study. They were divided as control and experimental groups of 30 each . Plaque index, Gingival index, Probing pocket depth, clinical attachment loss were recorded. The biochemical parameter serum albumin was correlated with periodontal status. Results: In experimental group serum albumin concentration ranged from 2.2 to 3.6g/dl with mean of 3.24 and found that sites of attachment loss 6mms and above had lower serum albumin level.It was inferred that sites 6mms loss of attachment had significant effect on serum albumin concentration. Conclusion: The mean serum albumin levels were significantly lower in subjects with 6mm and above of clinical attachment loss as compared to controls. It was concluded that there is an association between serum albumin and chronic periodontitis. However further longtitudinal and well controlled studies are required to evaluate the serum albumin and periodontal disease.