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AIM: To evaluate the clinical effect of trabeculectomy combined with amniotic membrane transplantation in the treatment of neovascular glaucoma(NVG). <p>METHODS: Forty-two cases(42 eyes)with NVG were performed trabeculectomy combined with amniotic membrane transplantation. The vision acuity, intraocular pressure(IOP), anterior chamber depth, hyphema, iris neovascularization and filtering bleb after operation were observed. All patients were followed up for 6-12 months. <p>RESULTS: IOP were controlled in less than 21mmHg in 34 cases postopeartively. Symptoms of 6 cases were alleviated, and the IOP were controlled in less than 21mmHg with treatment of carteolol hydrochloride eye drops 6-12 months after operation. <p>CONCLUSION:Trabeculectomy combined with amniotic membrane transplantation is an ideal treatment for NVG.