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As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a <i>Fusarium solani </i>strain, which is associated with the plant <i>Aglaonema hookerianum</i> Schott. FUS showed rapid and sub-micromolar IC₅₀ against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.