The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy
oleh: Flavia A. Graca, Mamta Rai, Liam C. Hunt, Anna Stephan, Yong-Dong Wang, Brittney Gordon, Ruishan Wang, Giovanni Quarato, Beisi Xu, Yiping Fan, Myriam Labelle, Fabio Demontis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates myofiber atrophy induced by cancer cachexia