A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus

oleh: Rafaela dos S. Peinado, Raphael J. Eberle, Raghuvir K. Arni, Mônika A. Coronado

Format: Article
Diterbitkan: MDPI AG 2022-10-01

Deskripsi

Since the intricate and complex steps in pathogenesis and host-viral interactions of arthropod-borne viruses or arboviruses are not completely understood, the multi-omics approaches, which encompass proteomics, transcriptomics, genomics and metabolomics network analysis, are of great importance. We have reviewed the omics studies on mosquito-borne viruses of the <i>Togaviridae</i>, <i>Peribuyaviridae</i> and <i>Phenuiviridae</i> families, specifically for Chikungunya, Mayaro, Oropouche and Rift Valley Fever viruses. Omics studies can potentially provide a new perspective on the pathophysiology of arboviruses, contributing to a better comprehension of these diseases and their effects and, hence, provide novel insights for the development of new antiviral drugs or therapies.