Mutation in West Nile Virus Structural Protein prM during Human Infection
oleh: Yaniv Lustig, Robert Lanciotti, Musa Hindiyeh, Nathan Keller, Ron Milo, Shlomo Mayan, Ella Mendelson
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2016-09-01 |
Deskripsi
A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.