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Neglected renal calculi can lead to a variety of complications secondary to obstruction and infection. Pyonephrosis arising in this scenario often presents as a urological emergency and requires urgent surgical intervention. In rare circumstances, when left unaided, the kidney is unable to contain the infection and spread of pus may occur into the surrounding spaces like the retroperitoneum and the peritoneum. We report a very unusual complication of pyonephrosis leading to a hepatic abscess. We believe this is the first reported case of an acute renal infection due to stone disease ascending into the liver.