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AIM: To evaluate the efficacy and safety of vitrectomy combined with internal limiting membrane(ILM)peeling for treating foveoschisis in high myopia.<p>METHODS: Thirty high-myopia patients(30 eyes)with foveoschisis from March 2011 to March 2013 were divided two groups: the treatment group(16 eyes)was treated with vitrectomy combined with ILM peeling, and the control group(14 eyes)was treated only with vitrectomy. The foveoschisis reattachment and and best spectacle-correction were measured preoperatively and 2mo after surgery.<p>RESULTS: The improvement of foveoschisis reattachment and best spectacle-correction in the treatment group was significantly better than those in the control group(<i>P<</i>0.05).<p>CONCLUSION: Vitrectomy combined with ILM peeling is a safe and effective treatment for foveoschisis in high myopia.