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Abstract From the perspective of configuration, this paper takes the region of manufacturing efficiency as the explanatory variable, selects eight antecedent conditions, and applies fuzzy set qualitative comparative analysis (fsQCA) to study the paths and methods of improving manufacturing emission efficiency. The results of the study show that there are two configuration paths of carbon emission efficiency in manufacturing industry, namely, research frontier and technological innovation level and labour force structure, R&D investment, science and technology innovation level, manufacturing output value, and environmental regulation synergistic path.