Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
oleh: Priyanka Baloni, Matthias Arnold, Luna Buitrago, Kwangsik Nho, Herman Moreno, Kevin Huynh, Barbara Brauner, Gregory Louie, Alexandra Kueider-Paisley, Karsten Suhre, Andrew J. Saykin, Kim Ekroos, Peter J. Meikle, Leroy Hood, Nathan D. Price, The Alzheimer’s Disease Metabolomics Consortium, P. Murali Doraiswamy, Cory C. Funk, A. Iván Hernández, Gabi Kastenmüller, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Complementary multi-omics approach, in silico metabolic flux, and neuroimaging analyses link the sphingolipid pathway to Alzheimer’s disease pathogenesis with therapeutic targets validated using behavioral assessments in amyloidogenic APP/PS1 mice.