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<i>Background and Objectives</i>: Acute pancreatitis (AP) is defined as an acute inflammatory disorder of the pancreas and is a common gastrointestinal disease. Since currently used indicators lack specifics and cannot accurately reflect the phase of disease, better diagnostic approaches need to be explored. Fibrinogen-like protein 1 (FGL-1) is a reactant in acute inflammatory diseases and is increased in the plasma of AP patients. In the current study, we aim to investigate the clinical benefits of FGL-1 in predicting the severity of AP and infected pancreatic necrosis (IPN), which can improve the diagnostic efficiency of AP. <i>Materials and Methods</i>: In this study, 63 patients diagnosed with AP from December 2018 to September 2019 were enrolled. Regarding the severity of AP, patients were separated into severe acute pancreatitis (SAP, <i>n</i> = 12) and No-SAP groups (<i>n</i> = 51). On the basis of infective conditions, patients were divided into IPN (<i>n</i> = 9) and No-IPN (<i>n</i> = 54) groups. The demographic data (sex and age) and blood parameters (WBC, HCT, glucose, calcium, FIB, APTT, PCT, CRP, and FGL-1) were retrospectively analyzed. <i>Results</i>: The plasma FGL-1 levels were increased in both SAP (<i>p</i> < 0.01) and IPN (<i>p</i> < 0.05) subgroups compared to the healthy control group. Multivariate analysis showed that elevated plasma FGL-1 (<i>p</i> < 0.01) and PCT levels (<i>p</i> < 0.05) within 72 h after the onset of AP were positively correlated with the severity of AP, while increased plasma FGL-1 (<i>p</i> < 0.01) and CRP (<i>p</i> < 0.05) levels were positively correlated with the occurrence of IPN. The combination of FGL-1 and PCT showed superiority to both individual markers in SAP prediction. However, the combination of FGL-1 and CRP showed no diagnostic advantage over CRP in IPN prediction. <i>Conclusions</i>: Plasma FGL-1 within 72 h after the onset could be used for the stratification of AP and its infectious complications. The combination of PCT and FGL-1 presents an enormous advantage for the early identification of SAP.