Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch
oleh: Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, Makoto Tsuda
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Gastrin-releasing peptide receptors (GRPR) are involved in pruriceptive behaviours. Here the authors show that neuronal pentraxin 2 upregulated in primary sensory neurons in chronic itch models is required for facilitating excitatory synaptic inputs onto GRPR expressing spinal neurons.