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This study examined Vietnamese local residents’ attitudes toward the reopening of their country to international tourists amid COVID-19 from March to April 2021. It began with a qualitative analysis of local residents’ opinions ( n  = 240) to identify the factors that could affect their attitudes, then continued with a review of the literature to create a theoretical model. Finally, the study implemented a structured survey to collect quantitative data ( n  = 412) to confirm the model. The outcomes revealed that “perceived vaccine efficacy” and “xenophobia” were two significant predictors of “attitude toward inbound tourism.” Implications of this study were then discussed.