Small molecule screen in embryonic zebrafish using modular variations to target segmentation

oleh: Sandra Richter, Ulrike Schulze, Pavel Tomançak, Andrew C. Oates

Format: Article
Diterbitkan: Nature Portfolio 2017-12-01

Deskripsi

Chemical screens can identify small molecules that affect biological development, with potential therapeutic value. Here, the authors use a modular approach in a screen in zebrafish embryos, varying concentration, genotype and timing to target segmentation disorders, birth defects that affect the spinal column.