The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
oleh: Liu Teng, Yu Chen Feng, Su Tang Guo, Pei Lin Wang, Teng Fei Qi, Yi Meng Yue, Shi Xing Wang, Sheng Nan Zhang, Cai Xia Tang, Ting La, Yuan Yuan Zhang, Xiao Hong Zhao, Jin Nan Gao, Li Yuan Wei, Didi Zhang, Jenny Y. Wang, Yujie Shi, Xiao Ying Liu, Jin Ming Li, Huixia Cao, Tao Liu, Rick F. Thorne, Lei Jin, Feng-Min Shao, Xu Dong Zhang
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding product of the 3q region, the lncRNA PLANE that promotes tumorigenesis through the deregulation of transcriptional corepressor NCOR2 pre-mRNA splicing.