Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
oleh: Jason T. White, Eric W. Cross, Matthew A. Burchill, Thomas Danhorn, Martin D. McCarter, Hugo R. Rosen, Brian O’Connor, Ross M. Kedl
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
Virtual memory T cells are CD8 T cells with memory phenotype present in unimmunized mice. Here the authors show that these cells have higher affinity for self-antigen, depend on IL-15 for proliferation and antigen-non-specific cytotoxicity in mice, and that a similar population exists in humans.