Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
oleh: Guillermo de la Rosa, Felipe Olvera, Irving G. Archundia, Bruno Lomonte, Alejandro Alagón, Gerardo Corzo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.